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The geographic coordinates (latitude and longitude) were collected for all houses and all participants were linked to their respective houses using a demographic surveillance system.

Written informed consent was obtained from all participants. Discussion: Spatial clustering within the villages was transient, making the prediction of spatial clusters difficult.

RESULTS: Respondents recognized malaria as a health concern and described the need for a malaria control program.

The risk of malaria including asymptomatic infection was explained in terms of participants' work in forest and fields, and poor hygiene.

The proportions of individuals predicted to receive optimal therapeutic PQ doses were: 73.2 (29,180/39,886), 93.7 (244,537/261,036), 99.6 (20,690/20,770), 99.4 (12,086/12,155) and 99.8% (327,620/328,132), respectively.

CONCLUSIONS: We plan to test the safety of this age-based dosing regimen in a large randomised placebo-controlled trial (ISRCTN11594437) of uncomplicated falciparum malaria in G6PDd African children aged 0.5 - 11 years. | Show Abstract | Read more BACKGROUND: As a part of targeted malaria elimination (TME) in the Greater Mekong Sub-region (GMS), mass drug administration (MDA) with anti-malarials was conducted in four villages in Nong District, Savannakhet Province, Lao PDR (Laos).

In all four villages, poverty affected access to healthcare and the provision of free care by TME was highly appreciated.The prevalence of k13 mutant parasites was much lower than the proportion of k13 mutants detected 200 km south in a much less remote setting where the prevalence of k13 mutants was 84% with 15 distinct alleles in 2013 of which C580Y predominated.CONCLUSIONS: This study provides evidence of artemisinin resistance in a remote part of eastern Myanmar. | Show Abstract | Read more Background: The malaria burden is decreasing throughout the Greater Mekong Subregion, however transmission persists in some areas.Methods: Three villages in Western Cambodia were selected for the study based on high reported Plasmodium falciparum incidence.A census was conducted at the beginning of the study, including demographic information and travel history. Cross-sectional surveys were conducted every three months from June 2013 to June 2014.

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